Libor Kozak, Rudy Gestede and Carlos Sanchez all look set to miss Tuesday's game with West Ham.
We face the Hammers at Upton Park, with a 7.45pm kick-off.
Kozak [ankle], Gestede [hamstring] and Sanchez [hamstring] could be absent after failing to recover from their injuries in time.
Ashley Westwood, who was withdrawn at half-time against Man City, is struggling to make the midweek encounter with a calf problem.
Alan Hutton [hamstring] and Kieran Richardson [calf] are also racing to be fit.
Boss Rémi Garde said: "I have a lot of players who won't be fit. I fear that. I will have to check with the doctor.
"I was told earlier that I could bring back either one or two strikers but probably Libor and Rudy won't be fit for West Ham. Carlos neither.
"Ashley is struggling with a pain on the calf. Alan is still struggling a little bit with his hamstring despite the fact I put him on the bench for the Man City match.
"Kieran also has a problem with his calf.
"I will probably have to make changes in the starting line-up."
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