Villa will be looking to recover from the weekend frustration of defeat to Stoke as Paul Lambert's men go back on the road. WhoScored.com are back to suggest why Villa could upset the odds again on Saturday, with their main man up front likely to play an integral role.
Both Villa and Man Utd will feel that they have something to prove this weekend - so there's likely to be plenty of action at either end.
The fact that both of these sides have picked up more points per game away from home this season than they have on home soil may well play into the hands of the visitors.
Villa will certainly be the underdogs but it's a status that they've thrived under this season.
With 10 points picked up against the current top four, Paul Lambert's young side certainly relish a challenge and while a trip to Old Trafford is still a daunting task, Man Utd have lost more league matches at home this season (6) than they had in the previous three combined.
David Moyes's team actually have the most points away from home in the Barclays Premier League but their struggles at Old Trafford have really held them back.
The reigning champions have scored just 18 times at home in the top-flight this term, with only West Brom, Norwich, Palace and Sunderland notching fewer.
With eight goals conceded in their last three league home matches, there's also reason for Villa to have hope from an attacking standpoint.
The visitors will look to top scorer Christian Benteke, who has scored each of the side's last two away goals, to provide the ammunition at Old Trafford.
The Belgian has been back on the goal trail of late, scoring six times in his last 10 appearances.
His WhoScored.com rating has soared in turn - and since the turn of the year - only Luis Suarez (8.52), Eden Hazard (8.08) and Daniel Sturridge (7.84) have averaged higher than his score of 7.82.
With three goals in three matches so far in March, the 23-year old rises even higher up the rankings, with only Suarez picking up a better WhoScored rating than the Villa forward this month (8.33).
The striker is clearly a man in form - and with United looking less watertight than usual - he'll hope to continue in the same vein.
A look at WhoScored.com's statistically-calculated team characteristics shows that United have a weakness when it comes to aerial duels.
With that in mind, Villa's target man could prove to be a tough customer to contend with, considering that he has won more aerial duels per game than any other player in the league this season (8.9).
Villa certainly have the weapons to hurt United at the business end and if they improve defensively again, who's to say they couldn't secure another high-profile scalp this weekend.
Find yet more statistics on Villa and the rest of the Premier League, including live in-game data and unique player and team ratings at WhoScored.com. Follow @WhoScored and their editor-in-chief @martinlaurence7 on Twitter.