Brad Guzan starred for USA as they emerged victorious 1-0 over Costa Rica in Colorado.
Tottenham's Clint Dempsey scored the winning goal in the 'North, Central America and Caribbean' Group.
USA are now second in the standings, one point behind Honduras.
Christian Benteke played eighty-five minutes in Belgium's 2-0 win in Macedonia.
He was replaced by Nacer Chadli but not before Kevin de Bruyne and Eden Hazard had won the Group A game in Skopje.
Alan Hutton played the full ninety minutes while Barry Bannan stayed on the bench as Scotland lost 2-1 at home to Wales in Group A.
Grant Hanley gave the Scots the lead but, following the dismissal of Richard Snodgrass, the Welsh came charging back thanks to goals from Aaron Ramsey and Hal Robson-Kanu.
Belgium are top of Group A with thirteen points from five games while Scotland are bottom with two points from five games.
Ciaran Clark played the full ninety minutes as Republic of Ireland drew 0-0 against Sweden in Stockholm in the Group C encounter.
Andreas Weimann played twenty-seven minutes, but didn't find the net, in Austria's 6-0 win over Faroe Islands in Group C. He replaced Andreas Ivanschitz.
Republic of Ireland and Austria are joint third in Group C with seven points from four games.
Ron Vlaar remained on the bench as Holland won 3-0 at home to Estonia in Group D. Rafael Van Der Vaart, Robin van Persie and Ruben Schaken bagged the goals.
Holland are top of Group D with a maximum fifteen points from five games.
The top team in each group progresses to the finals.
The second placed side from each group will contest round two of qualifying.
The teams will be paired into four home-and-away ties.
The matches will be played between November 15 and 19 and the winners also make it through to Brazil.
Make sure you snap up tickets for Villa v Liverpool.